After her son is gunned down by Joe Chill, Martha descends into insanity cradling her sons body; Martha's "Joker smile" was from her son's blood as her sorrow turns into insane laughter. the result being that while Thomas becomes this universes Batman, Martha becomes The Joker. Batman later fights Yo-Yo for the Joker's whereabouts and the location of Judge Dent's twin children. Thomas also compares Eobard Thawne's deranged psychosis to the Joker's insanity.
When her son Bruce was ten, Martha and her husband Thomas were murdered in front of him.
- Justice League: The Flashpoint Paradox
- Justice League: War (mentioned)
- Batman vs. Robin
- Batman: Bad Blood
- Martha Wayne first appeared in Detective Comics #33 created by Bob Kane and Bill Finger.