Like the 2003 animated series, he is the leader of H.I.V.E., which is in this version a cult seeking divine dominion over mankind. Blood has Deathstroke and Terra kidnap most of the Teen Titans in order to drain their powers and thus make himself into a god-like being. However, the plan is thwarted by Nightwing (the only Titan who escaped the scheme) and an enraged Terra, who was betrayed by Deathstroke. He gets halfway there, failing to drain them completely but still getting their powers.
In the end, Blood is depowered by Raven and slain by his aide, Mother Mayhem, to prevent him from being imprisoned; their bodies are subsequently crushed by debris when Terra causes the H.I.V.E. temple to collapse.